Cancer BiologybioRxiv
PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer
T. H. Truong, E. A. Benner, K. M. Hagen…·J. H. Ostrander
This study identifies PELP1/SRC-3-dependent regulation of metabolic kinases as a driver of therapy-resistant ER+ breast cancer and shows that targeting PFKFBs can block tumorsphere formation in resistant models.
DOI 10.1038/s41388-021-01871-w