Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination
J. Herskovitz, M. Hasan, M. Patel, W. R. Blomberg, J. D. Cohen, J. Machhi, D. Stein, E. A. Schroder, J. McMillan, C. Gurumurthy, B. D. Kevadiya, H. E. Gendelman
This paper designs CRISPR-Cas9 guide RNAs targeting HIV-1 exons to reduce viral load in infected cells without off-target effects.
bioRxiv · Jan 14, 2021Microbiology