M. Hasan

Differential predictive value of resident memory CD8+T cell subpopulations in non-small-cell lung cancer patients treated by immunotherapy

The paper identifies two TRM subpopulations in NSCLC patients and shows that only DP TRM predicts response to PD-1 blockade immunotherapy.

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

Beyond 40 fluorescent probes for deep phenotyping of blood mononuclear cells, using spectral technology.

This paper presents a 43-parameter flow cytometry panel for analyzing peripheral blood mononuclear cells, demonstrating improved resolution and reproducibility through spectral technology and optimized experimental design.

High-dimensional spectral cytometry panels for whole blood immune phenotyping

The paper develops high-dimensional spectral flow cytometry panels for immune phenotyping in healthy donors and applies them to study immune variation in autoimmune diseases.

Requirement for specific bacterial genome maintenance pathways in repair of C8-linked pyrrolobenzodiazepine (PBD) bi-aryl monomer-mediated DNA damage

This study investigates how C8-linked PBD bi-aryl monomers cause DNA damage in Caulobacter crescentus and identifies the repair mechanisms required for survival.

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

Dynamic Expedition of Leading Mutations in SARS-CoV-2 Spike Glycoproteins

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F420 and its derivative 3PG-F420

This paper identifies amino acids governing substrate specificity in CofC, reveals a labile reaction product, and shows CofD's role in controlling biosynthesis of 3PG-F420.

The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.

Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination

This paper designs CRISPR-Cas9 guide RNAs targeting HIV-1 exons to reduce viral load in infected cells without off-target effects.

Comprehensive Genome Based Analysis of Vibrio parahaemolyticus for Identifying Novel Drug and Vaccine Molecules: Subtractive Proteomics and Vaccinomics Approach

This study identifies novel drug and vaccine targets for Vibrio parahaemolyticus using genome-based analysis, subtractive proteomics, and vaccinomics approaches.

Unveiling the inter individual variability of human fibroblasts innate immune response using robust cell-based protocols

This study develops standardized in vitro protocols to quantify inter-individual variability in human fibroblast innate immune responses using primary cells from a clinical cohort.

Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric Vaccine

This study predicts a chimeric vaccine targeting four SARS-CoV-2 proteins by analyzing conserved regions and epitopes, identifying construct V3 as the most effective candidate.

Antimicrobial Resistance Profile and mcr-1 gene Detection in Salmonella Isolates from Poultry in Bangladesh: Molecular and Bioinformatics Characterization

The paper detects the mcr-1 gene in Salmonella isolates from poultry in Bangladesh using PCR and bioinformatics analysis, revealing colistin resistance mechanisms.

Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420

The paper identifies novel F420 derivatives in Paraburkholderia rhizoxinica, reveals their biosynthesis pathway, and demonstrates their functional activity and potential for biocatalysis.

Phytochemical Constituency Profiling and Antimicrobial Activity Screening of Seaweeds Extracts Collected from the Bay of Bengal Sea Coasts

This study evaluates the phytochemical composition and antimicrobial activity of two seaweed species from the Bay of Bengal, finding higher phenolic content and antimicrobial efficacy in Hypnea musciformis compared to Enteromorpha intestinalis.