IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit
A. Latifkar, F. Wang, J. J. Mullmann, I. R. Fernandez, L. Ling, C. Fischbach, R. S. Weiss, H. Lin, R. A. Cerione, M. A. Antonyak
The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.
bioRxiv · Apr 1, 2021Cell Biology