Cell BiologybioRxiv
IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit
A. Latifkar, F. Wang, J. J. Mullmann…·M. A. Antonyak
The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.
DOI 10.1073/pnas.2200477119