L. Ling

Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to Plasmodium falciparum

The paper examines spatial transcriptomic and proteomic profiles of Hofbauer cells in placentas with and without past Plasmodium falciparum infection, finding no significant differences in HBC features but reduced fetal vessel development in infected placentas.

Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23

This study investigates the effects of conditional knockdown of mitochondrial ribosomal proteins RSM22 and L23 in Plasmodium falciparum, revealing distinct transcriptional responses and metabolic defects leading to parasite death.

Malaria parasites utilize pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage

This study shows that malaria parasites use pyrophosphate to power a proton pump essential for ring stage development and transition to trophozoite stage.

The Impact of a Dynamic Working Environment on Human Gut Microbiota

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit

The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.

In vitro rapid inactivation of SARS-CoV-2 by visible light photocatalysis using boron-doped bismuth oxybromide

This study demonstrates that boron-doped bismuth oxybromide rapidly inactivates SARS-CoV-2 under visible light and in the dark, outperforming conventional photocatalysts.

Interactive Web-based Annotation of Plant MicroRNAs with iwa-miRNA

The paper introduces iwa-miRNA, a web-based tool for interactive annotation of plant miRNAs using sRNA-Seq data and manual curation.

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

This study identifies ESRP2 as an epigenetically repressed tumour suppressor in Wilms tumour through DNA hypermethylation, showing its ability to inhibit proliferation and suppress tumour growth.

Plant endophytic bacteria: a potential resource pool of electroactive microorganisms

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen

A dispensable role of mitochondrial fission protein 1 (Fis1) in the erythrocytic development of Plasmodium falciparum

This study shows that Fis1 is not essential for mitochondrial fission in Plasmodium falciparum, suggesting the presence of other fission adaptor proteins.

Genetic ablation of the mitochondrial ribosome in Plasmodium falciparum sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functions

This study shows that disrupting the mitochondrial ribosome in Plasmodium falciparum makes the parasite more sensitive to drugs targeting mitochondrial functions.

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.