Author

J. Jaffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Chakraborty· 1 shared A. Creech· 1 shared A. Ringel· 1 shared B. Olenchock· 1 shared D. M. Weinreich· 1 shared J. Spinelli· 1 shared M. Booker· 1 shared M. Haigis· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Chakraborty

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Author profile →

2 papers

Recent·Most cited

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

A. Chakraborty, T. Laukka, M. Myllykoski, A. Ringel, M. Booker, M. Tolstorukov, Y. Meng, S. Meier, R. Jennings, A. Creech, Z. Herbert, J. Spinelli, S. McBrayer, B. Olenchock, J. Jaffe, , W. G. Kaelin

The paper shows that KDM6A, an H3K27 histone demethylase, is oxygen-sensitive and its inactivation under hypoxia affects chromatin and cell fate.

bioRxiv · Jan 3, 2019 · PreprintBiochemistry

The influence of higher-order epistasis on biological fitness landscape topography

D. M. Weinreich, Y. Lan, J. Jaffe, R. B. Heckendorn

This study examines how higher-order epistasis affects the topography of biological fitness landscapes and finds that its effects generally decline with order.

bioRxiv · Jul 18, 2017Evolutionary Biology