Author

S. Meier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

H. Ginn· 3 shared A. Peck· 2 shared A. Tolstikova· 2 shared B. Norton-Baker· 2 shared B. Seychell· 2 shared C. Ehrt· 2 shared C. Li· 2 shared D. Oberthuer· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

H. Ginn

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

D. D. Klysz, C. Fowler, M. Malipatlolla, L. Stuani, K. A. Freitas, S. Meier, B. Daniel, K. Sandor, P. Xu, J. Huang, L. Labanieh, A. Leruste, M. Bashti, V. Keerthi, J. Mata-Alcazar, , C. L. Mackall

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

bioRxiv · Apr 21, 2023Immunology

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

B. Shuoker, M. J. Pichler, C. Jin, H. Sakanaka, H. Wu, A. Ana Martinez Gascuena, J. Liu, T. S. Nielsen, J. Holgersson, E. Nordberg Karlsson, N. Juge, S. Meier, J. P. Morth, N. G. Karlsson, M. Abou Hachem

This study identifies sialidases and fucosidases in Akkermansia muciniphila that degrade mucin glycans and enable nutrient sharing with gut bacteria.

bioRxiv · Sep 10, 2022 · PreprintBiochemistry

Reversible supramolecular assembly of the anti-microbial peptide plectasin into helical non-amyloid fibrils

C. Pohl, G. Effantin, E. Kandiah, S. Meier, G. Zeng, W. Streicher, G. H. Peters, G. Schoehn, C. Mueller-Dieckmann, A. Noergaard, P. Harris

The paper shows that a triple-mutant of plectasin forms reversible helical non-amyloid fibrils, with high-resolution structure and pH-dependent equilibrium.

bioRxiv · Sep 6, 2021 · PreprintBiophysics

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

S. Guenther, P. Y. A. Reinke, Y. Fernandez-Garcia, J. Lieske, T. J. Lane, H. Ginn, F. Koua, C. Ehrt, W. Ewert, D. Oberthuer, O. Yefanov, S. Meier, K. Lorenzen, B. Krichel, J. Kopicki, , Schwi

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

bioRxiv · Nov 12, 2020Biophysics

Untangling mechanisms of crude oil toxicity: linking gene expression, morphology and PAHs at two developmental stages in a cold-water fish

E. Sorhus, C. E. Donald, D. Dasilva, A. Thorsen, O. Karlsen, S. Meier

This study examines crude oil toxicity in Atlantic haddock by analyzing gene expression, morphology, and PAHs at two developmental stages, finding that early exposure causes more severe abnormalities.

bioRxiv · Sep 9, 2020Biochemistry

Serial femtosecond and serial synchrotron crystallography yield data of equivalent quality: a systematic comparison

P. Mehrabi, R. Buecker, G. Bourenkov, H. Ginn, D. von Stetten, H. M. Mueller-Werkmeister, A. Kuo, T. Morizumi, B. Eger, W.-L. Ou, S. Oghbaey, A. Sarracini, J. Besaw, O. Pare-Labrosse, S. Meier, , R. J. D. Miller

This study compares data quality from serial femtosecond and serial synchrotron crystallography for two proteins, finding equivalent quality regardless of radiation source.

bioRxiv · Aug 21, 2020Biophysics

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

S. Günther, P. Y. A. Reinke, D. Oberthuer, O. Yefanov, H. Ginn, S. Meier, T. J. Lane, K. Lorenzen, L. Gelisio, W. Brehm, I. Dunkel, M. Domaracky, S. Saouane, J. Lieske, C. Ehrt, , G

The paper presents the crystal structure of SARS-CoV-2 main protease covalently bound to a metabolite of HEAT, revealing a pro-drug mechanism and potential for non-peptidic inhibitors.

bioRxiv · May 2, 2020 · PreprintBiophysics

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

A. Chakraborty, T. Laukka, M. Myllykoski, A. Ringel, M. Booker, M. Tolstorukov, Y. Meng, S. Meier, R. Jennings, A. Creech, Z. Herbert, J. Spinelli, S. McBrayer, B. Olenchock, J. Jaffe, , W. G. Kaelin

The paper shows that KDM6A, an H3K27 histone demethylase, is oxygen-sensitive and its inactivation under hypoxia affects chromatin and cell fate.

bioRxiv · Jan 3, 2019 · PreprintBiochemistry