Y. Lan

Low protein diet protects liver function upon Salmonella infection by metabolic reprogramming of macrophages

This study shows that a low protein diet reduces liver damage from Salmonella infection by altering macrophage metabolism and autophagy.

EI24-RTRAF interaction represses Nox4 translation, vital for redox balance and insulin production

The paper identifies EI24-RTRAF interaction as a regulator of Nox4 translation, maintaining redox balance and insulin production in pancreatic beta cells.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid Arthritis.

This study shows that 3D environments influence fibroblast inflammation in rheumatoid arthritis, with soft hydrogels promoting a resolving phenotype and stiff scaffolds restoring inflammatory profiles.

Restoring glucose homeostasis with stomach-derived human insulin-secreting organoids

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

Ecological differences among hydrothermal vent symbioses may drive contrasting patterns of symbiont population differentiation

This study compares symbiont population differentiation in deep-sea mussels with different ecological niches, finding that habitat homogeneity and mixotrophy reduce geographic structuring of symbiont strains.

HDL-C as a potential medium between depletion of Lachnospiraceae genera and hypertension under high-calorie diet

This study links gut microbial depletion of Lachnospiraceae genera to lower HDL-C and hypertension in a high-calorie diet population, suggesting HDL-C as a mediator.

Pericentriolar matrix integrity relies on cenexin and Polo-Like Kinase (PLK)1

This study identifies cenexin's role in maintaining pericentriolar matrix integrity through PLK1-dependent phosphorylation in human and zebrafish cells.

OsciDrop: A versatile on-demand droplet generator

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

The paper identifies Fascin as a regulator of Myosin activity in Drosophila border cells, showing it controls substrate stiffness to enhance migration.

Tripartite holobiont system in a vent snail broadens the concept of chemosymbiosis

The paper investigates the genomic basis of symbiosis in a vent snail, revealing a tripartite holobiont system involving host, endosymbionts, and gut microbiota, highlighting metabolic flexibility and mutualistic interactions.

What determines the FDC polarization and GC size in affinity maturation

The paper establishes a spatiotemporal stochastic model to simulate GC self-organization and finds that GC size and structure influence affinity maturation and antibody production.

Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes

This study quantifies inter-TAD interactions in human cells and shows cohesin depletion reduces both intra- and inter-domain interactions, affecting gene expression near boundaries.

SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis

This study shows that SMCR8 regulates MTORC1 and AKT signaling, affecting lysosome biogenesis and tissue homeostasis, with loss of SMCR8 causing splenomegaly and autoimmune-like phenotypes.

Natural selection can favor ratchet robustness over mutational robustness

The paper shows that natural selection can favor ratchet robustness over mutational robustness due to long-term extinction risks from Muller's ratchet.

ADS-J1 Disaggregates Semen-derived Amyloid Fibrils

ADS-J1 disassembles semen-derived amyloid fibrils and prevents their re-aggregation, showing potential as a microbicide and treatment for amyloid diseases.

The influence of higher-order epistasis on biological fitness landscape topography

This study examines how higher-order epistasis affects the topography of biological fitness landscapes and finds that its effects generally decline with order.