Y. Meng

Acidotolerant soil nitrite oxidiser 'Candidatus Nitrobacter laanbroekii' NHB1 alleviates constraints on growth of acidophilic soil ammonia oxidisers

This study characterizes the growth of Nitrobacter strain NHB1 under acidic conditions and shows its role in enhancing ammonia oxidation by acidophilic archaea in co-culture.

AI-driven high-throughput droplet screening of cell-free gene expression

This paper introduces DropAI, an AI-driven droplet-based screening method to optimize cell-free gene expression systems, achieving cost reduction and yield improvement.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Impact of genomic background and developmental state on signaling pathways and response to therapy in Glioblastoma patient-derived cells

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

This study shows ATG6 interacts with NPR1, enhancing its nuclear accumulation and stability, which boosts Arabidopsis resistance to Pst DC3000/avrRps4.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

Viscoelastic Deformability Cytometry: Ultra-high Throughput Platform for Mechanical Phenotyping of Cells in Liquid and Solid Biopsies

This paper introduces a high-throughput microfluidic platform for measuring cell mechanical properties in liquid and solid biopsies, enabling rapid and accurate mechanical phenotyping of cancer cells.

Impossible ecologies: Interaction networks and stability of coexistence in ecological communities

This paper shows that the arrangement of interactions in ecological networks can significantly affect the stability of coexistence, identifying 'impossible ecologies' where stable coexistence is non-trivially impossible.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Ground-state pluripotent stem cells are characterized by Rac1-dependent Cadherin-enriched F-actin protrusions

This study identifies cadheropodia, Rac1-dependent actin structures in ground-state mESCs, which may serve as markers for pluripotency.

A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes

The paper identifies biosynthetic pathways for eukaryotic toxins in daffodils by showing that toxin production is localized to growing tissues.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

Integrated multi-omics data reveals the molecular subtypes and the contruction of novel signature to aid Immunotherapy

The paper identifies two molecular subtypes of lung adenocarcinoma using multi-omics data and develops a signature to predict immunotherapy response.

Genomic determinants of soil depth niche partitioning in Gagatemarchaeaceae, a novel family of deeply-rooted Thaumarchaeota

This study analyzes 15 new genomes of Gagatemarchaeaceae from acidic soils to understand their genomic and metabolic adaptations to different soil depths.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

This study analyzes monkeypox virus-host cell interactions using transcriptome data to identify signaling pathways, biomarkers, and potential drug candidates.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

The role and mechanism of NRF2 in endothelial cells and smooth muscle cells of pulmonary artery

The paper investigates NRF2's role in pulmonary artery endothelial and smooth muscle cells under hypoxia, finding differential regulation and effects on proliferation and migration.

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

Predicting plant-related and leaf-related parameters of winter wheat using vegetation index: Should phenological correction be applied across growth stages?

This study evaluates whether a unified model can predict plant and leaf parameters of winter wheat using vegetation indices across growing seasons, finding that hierarchical linear models (HLM) are stable and applicable across seasons for most parameters.

Mechanism of Voltage Gating in the Voltage-Sensing Phosphatase Ci-VSP

The paper investigates the voltage gating mechanism of Ci-VSP's voltage-sensing domain using simulations and experiments, identifying four states and charge movement during activation.

Comparative miRNA Transcriptomics of Mouse and Macaque Reveals MYOC is An Inhibitor for C. neoformans Invasion into Brain

The new archaeal order Lutiacidiplasmatales reveals convergent evolution in Thermoplasmatota

This study identifies a new archaeal order, Lutiacidiplasmatales, and shows that key metabolisms evolved convergently in Thermoplasmatota lineages.

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

The paper identifies platelet-biased human hematopoietic stem cells (HSCs) and shows their proportion and transcriptional platelet priming increase with age.

Repression of MAPK/Erk signaling by Efnb2-Ephb4-Rasa1 is required for lymphatic valve formation

This study identifies the role of Efnb2-Ephb4-Rasa1 in repressing MAPK/Erk signaling to regulate lymphatic valve formation and suggests potential therapeutic targets.

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.