Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses
B. S. Ou, J. Baillet, M. V. Filsinger Interrante, J. Z. Adamska, X. Zhou, O. Saouaf, J. Yan, J. Klich, C. K. Jons, E. Meany, A. S. Valdez, L. Carter, B. Pulendran, N. P. King, E. Appel
This paper develops a modular saponin-based nanoparticle adjuvant platform incorporating TLR agonists, showing improved vaccine potency and breadth against COVID-19 and HIV in mice.
bioRxiv · Jul 16, 2023 · PreprintBioengineering