B. Pulendran

Computationally designed mRNA-launched protein nanoparticle vaccines

This paper develops an mRNA-launched nanoparticle vaccine that combines protein nanoparticle and mRNA vaccine advantages, showing enhanced antibody and T cell responses in mice.

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.

Integrated Organ Immunity: Antigen-specific CD4-T cell-derived IFN-γ induced by BCG imprints prolonged lung innate resistance against respiratory viruses

Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses

This paper develops a modular saponin-based nanoparticle adjuvant platform incorporating TLR agonists, showing improved vaccine potency and breadth against COVID-19 and HIV in mice.

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2

This study identifies potent pan-sarbecovirus neutralizing antibodies from vaccinated macaques, showing broad neutralization against SARS-CoV-2 variants and related viruses.

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

This paper describes a ferritin-based nanoparticle vaccine, DCFHP-alum, that induces strong, long-lasting neutralizing antibodies against SARS-CoV-2 variants in non-human primates.

Designing epitope-focused vaccines via antigen reorientation

This paper introduces an antigen reorientation strategy using oligoD insertion to shift immune responses toward conserved epitopes, demonstrating improved cross-reactivity in influenza vaccines.

Inhibition of CHK2 dependent DNA damage response suppresses Zika virus infection through a STING dependent mechanism

This study shows that inhibiting CHK2 reduces ZIKV production and rescues developmental defects by enhancing STING-dependent antiviral responses.

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

The paper integrates transcriptional data from 13 vaccines to identify a time-adjusted signature predicting antibody responses across different vaccines.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

This study compares neutralizing antibody responses to SARS-CoV-2 variants in vaccinated humans and mice, finding that mice do not accurately reflect the breadth and potency seen in humans.

Durability of immune responses to the BNT162b2 mRNA vaccine

This study shows that antibody and T cell responses to the BNT162b2 vaccine wane significantly at 6 months, suggesting a potential need for a third booster dose.

Safety, immunogenicity and protection provided by unadjuvanted and adjuvanted formulations of recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in non-human primates

This study evaluates the safety and immunogenicity of a plant-derived VLP vaccine against SARS-CoV-2 in non-human primates, finding that AS03 adjuvanted vaccine provides better protection and immune response.

Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2

This study shows that slow release of an RBD subunit vaccine via hydrogel enhances neutralizing antibody responses against SARS-CoV-2 compared to bolus administration.

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.

STAT5: A Target of Antagonism by Neurotropic Flaviviruses

The paper identifies STAT5 as a target of antagonism by WNV and ZIKV in human DCs, showing differential inhibition of Jak kinases compared to other flaviviruses.

West Nile Virus Subverts T Cell Stimulatory Capacity of Human Dendritic Cells

This study shows West Nile virus infects human dendritic cells, activates antiviral responses, but suppresses T cell activation and cytokine production, impairing T cell immunity.

ImmuneRegulation: A web-based tool for identifying human immune regulatory elements

ImmuneRegulation identifies human immune regulatory elements by integrating eQTLs, TF binding regions, and GWAS data to explore gene regulation in blood cell types.