In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening
R. R. Paschke, S. Mohr, S. Lange, A. Lange, J. Kozuch
This study uses SEIRA spectroscopy to observe large-scale reorientation of M2 transmembrane α-helices during pH-activated channel opening, showing how rimantadine inhibits this motion.
bioRxiv · Jun 22, 2023Biophysics