BiophysicsbioRxiv
In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening
R. R. Paschke, S. Mohr, S. Lange…·J. Kozuch
This study uses SEIRA spectroscopy to observe large-scale reorientation of M2 transmembrane α-helices during pH-activated channel opening, showing how rimantadine inhibits this motion.
DOI 10.1002/anie.202309069