A. Lange

The genomic signature and transcriptional response of metal tolerance in brown trout inhabiting metal-polluted rivers

This study investigates the genomic and transcriptomic signatures of metal tolerance in brown trout from metal-polluted rivers, identifying genetic and gene expression changes associated with metal resistance.

In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening

This study uses SEIRA spectroscopy to observe large-scale reorientation of M2 transmembrane α-helices during pH-activated channel opening, showing how rimantadine inhibits this motion.

Experimental characterisation of de novoproteins and their unevolved random-sequencecounterparts

The paper experimentally compares de novo proteins and synthetic random-sequence proteins to assess their solubility and structure propensity, finding de novo proteins are more soluble.

A scalable, clinically severe pig model for Duchenne muscular dystrophy

This paper develops a scalable pig model for Duchenne muscular dystrophy by breeding DMD carriers, enabling large cohorts for disease mechanism studies and therapeutic testing.

Structural and functional characterization of a putative de novo gene in Drosophila

The paper characterizes a de novo gene in Drosophila, showing its structural features and role in male fertility through biochemical and evolutionary analyses.

Spinal Column Architecture of the Flexible SPP1 Bacteriophage Tail Tube

The paper determines the structure of the flexible tail tube of bacteriophage SPP1 using solid-state NMR and cryo-EM.