S. Lange

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

This study identifies TOM20, TOM70, TOM40, and associated subunits as critical for PINK1 activation in a reconstituted yeast system, providing insights for PINK1 activator development.

In-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening

This study uses SEIRA spectroscopy to observe large-scale reorientation of M2 transmembrane α-helices during pH-activated channel opening, showing how rimantadine inhibits this motion.

An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates

This study identifies and characterizes a novel E3 ligase module in UBR4, revealing its structural and biochemical specificity for UBE2A and its role in the N-degron pathway.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

Interaction with C21ORF2 controls the cellular functions of the NEK1 kinase

This study identifies C21ORF2 as a regulatory subunit of NEK1, showing that their interaction is critical for NEK1 function and that mutations disrupt this interaction, linking it to disease.

Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.

This study shows that loss of obscurin and Obsl1 in mice causes diastolic dysfunction, altered metabolism, and deregulated mitophagy in the heart.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

Peptidylarginine Deiminase inhibition abolishesthe production of large extracellular vesicles fromGiardia intestinalis, affecting host-pathogeninteractions by hindering adhesion to host cells.

This study shows that inhibiting peptidylarginine deiminase (PAD) reduces large extracellular vesicle production in Giardia intestinalis, impairing host-pathogen adhesion.