Author

J. Kugel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

E. Ly· 2 shared J. Goodrich· 2 shared A. E. Powell· 1 shared A. Scott· 1 shared A. Swearingen· 1 shared B. Seelbinder· 1 shared C. Neu· 1 shared C. Van Den Elzen· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

E. Ly

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Author profile →

3 papers

Recent·Most cited

Epigenetic remodeling during monolayer cell expansion reduces therapeutic potential

A. Scott, E. Casas, S. E. Schneider, A. Swearingen, C. Van Den Elzen, B. Seelbinder, J. Barthold, J. Kugel, J. L. Stern, K. Foster, N. Emery, J. Brumbaugh, C. Neu

This study shows that mechanical memory in chondrocytes is encoded in chromatin architecture, affecting their fate and therapeutic potential after expansion.

bioRxiv · Dec 14, 2021 · PreprintBioengineering

Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites

E. Ly, J. Kugel, J. Goodrich

This study uses single molecule fluorescence to show p53 tetramers bind DNA response elements with varying half-site configurations, revealing kinetic stability depends on half-site number and phasing.

bioRxiv · Dec 19, 2019Biochemistry

Release of human TFIIB from actively transcribing complexes is triggered upon synthesis of 7 nt and 9 nt RNAs

E. Ly, A. E. Powell, J. Goodrich, J. Kugel

The paper investigates TFIIB release during transcription using a single molecule fluorescence system and finds it occurs at two points with similar kinetics, supporting its role in maintaining Pol II activity during transition to elongation.

bioRxiv · Dec 19, 2019Biochemistry