A. Scott

Comparative Analysis of Neural Crest Development in the Chick and Mouse

The paper identifies conserved and divergent transcriptional signatures in neural crest cells across chick and mouse embryos during migration.

Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

The paper identifies distinct mononuclear phagocyte populations in the adult zebrafish heart and shows their differential distribution and behavior, including proliferation after injury.

Phylogenomics reveals coincident divergence between giant host sea anemones and the clownfish adaptive radiation.

This paper uses phylogenomic analysis to show that clownfish-hosting sea anemones diversified coincidently with clownfishes, supporting co-evolutionary patterns in their mutualistic relationship.

LSD1/KDM1A is essential for neural stem cell differentiation in mice

This study shows that LSD1/KDM1A is essential for neural stem cell differentiation in mice, as its deletion causes perinatal lethality and brain defects, but motor neurons can still be generated.

Modeling Cystic Fibrosis Chronic Infection Using Engineered Mucus-like Hydrogels

This study develops mucus-like hydrogels to model cystic fibrosis airway infections and finds that antibiotic resistance depends on both hydrogel properties and culture conditions.

Genetic characterization of extended-beta-lactamase (ESBL) plasmids captured from dairy manures

This study characterizes ESBL-carrying plasmids from dairy manure using hybrid sequencing, revealing diversity in incompatibility groups, resistance genes, and mobile elements.

Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical antibiotic concentrations

This study determines the minimum selection concentrations of antibiotics for manure-originated multi-drug resistant plasmids in E. coli, showing they can be maintained in environmentally relevant concentrations.

Seagrass genomes reveal a hexaploid ancestry facilitating adaptation to the marine environment

This study presents chromosome-level genome assemblies of seagrass species and identifies ancient and recent genome duplication events linked to adaptation to marine environments.

Paracrine CSF1 signaling regulates macrophage migration dynamics towards ovarian cancer cells in a 3D microfluidic model that recapitulates in vivo infiltration patterns in patient-derived xenograft models

This study shows that CSF1 signaling drives macrophage migration toward ovarian cancer cells in a 3D microfluidic model, mirroring in vivo patterns in patient-derived xenografts.

Epigenetic remodeling during monolayer cell expansion reduces therapeutic potential

This study shows that mechanical memory in chondrocytes is encoded in chromatin architecture, affecting their fate and therapeutic potential after expansion.

Nuclear stiffness decreases with disruption of the extracellular matrix in living tissues

The paper measures nuclear stiffness in native tissues and finds that matrix disruption reduces both tissue and nuclear stiffness.

Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiome.

This study investigates the impact of Giardia infection on gut microbiome structure in dogs and children, finding significant microbiome remodeling associated with infection.

In vivo characterisation of endogenous cardiovascular extracellular vesicles in larval and adult zebrafish

This study develops a transgenic zebrafish model to track and extract endogenous cardiovascular extracellular vesicles (EVs) in vivo, showing their production by multiple cell types and dynamic changes under injury.

TENSCell: A 3D-Printed Device for High-Magnification Imaging of Stretch-Activated Cells Reveals Divergent Nuclear Behavior to Different Levels of Strain

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA

This study identifies 5-hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA to detect early-stage pancreatic cancer with high accuracy.

Identification of regulatory targets for the bacterial Nus factor complex

The paper identifies regulatory targets of the bacterial Nus factor complex, showing it represses its own gene and regulates other genes through translation inhibition and Rho-dependent termination.