Elevated Lactate in the AML Bone Marrow Microenvironment Polarizes Leukemia-Associated Macrophages via GPR81 Signaling
C. A. Soto, M. L. Lesch, J. L. Becker, A. Sharipol, A. Khan, X. L. Shafer, M. W. Becker, J. C. Munger, B. J. Frisch
This study identifies lactate as a key factor in AML-induced immunosuppression by polarizing leukemia-associated macrophages via GPR81 signaling.
bioRxiv · Nov 13, 2023 · PreprintPathology