Author

M. L. Lesch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Khan· 1 shared A. L. Hughson· 1 shared A. Sharipol· 1 shared B. J. Frisch· 1 shared B. N. Mills· 1 shared C. A. Soto· 1 shared C. A. Stockwell· 1 shared C. J. Johnston· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPathology

A. Khan

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Elevated Lactate in the AML Bone Marrow Microenvironment Polarizes Leukemia-Associated Macrophages via GPR81 Signaling

C. A. Soto, M. L. Lesch, J. L. Becker, A. Sharipol, A. Khan, X. L. Shafer, M. W. Becker, J. C. Munger, B. J. Frisch

This study identifies lactate as a key factor in AML-induced immunosuppression by polarizing leukemia-associated macrophages via GPR81 signaling.

bioRxiv · Nov 13, 2023 · PreprintPathology

Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer

A. L. Hughson, G. Hannon, N. A. Salama, T. G. Vrooman, C. A. Stockwell, B. N. Mills, J. Garrett-Larsen, H. Qui, R. Katerji, L. Benoodt, C. J. Johnston, J. D. Murphy, E. Kruger, J. Ye, N. W. Gavras, , S. A. Gerber

This paper demonstrates a combination treatment of SBRT and IL-12 mRNA in murine pancreatic tumors, achieving cures in both primary and metastatic models by enhancing T cell responses.

bioRxiv · Oct 30, 2023 · PreprintCancer Biology