Author

J. L. Fiddler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:metabolomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

M. S. Field· 3 shared A. E. Thalacker-Mercer· 2 shared J. E. Blum· 2 shared W. N. Phinney· 2 shared Y. Xiu· 2 shared C. Metallo· 1 shared J. T. Brosnan· 1 shared K. E. Heyden· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

M. S. Field

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Author profile →

3 papers

Recent·Most cited

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

K. E. Heyden, J. L. Fiddler, Y. Xiu, O. V. Malysheva, M. K. Handzlik, W. N. Phinney, L. Stiles, S. S. Stabler, C. Metallo, M. A. Caudill, M. S. Field

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

bioRxiv · Aug 29, 2022 · PreprintBiochemistry

Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

J. L. Fiddler, J. E. Blum, L. F. Castillo, A. E. Thalacker-Mercer, M. S. Field

This study shows reduced SHMT2 expression or folate availability impairs mitochondrial function, pyruvate kinase activity, and cellular proliferation in cell models.

bioRxiv · Apr 7, 2022 · PreprintBiochemistry

Reduced Shmt2 expression impairs mitochondrial folate accumulation and respiration, and leads to uracil accumulation in mouse mitochondrial DNA

J. L. Fiddler, Y. Xiu, J. E. Blum, S. G. Lamarre, W. N. Phinney, S. P. Stabler, M. E. Brosnan, J. T. Brosnan, A. E. Thalacker-Mercer, M. S. Field

This study shows that reduced Shmt2 expression and folate deficiency impair mitochondrial dTMP synthesis, increase uracil in mtDNA, and reduce mitochondrial function in mice.

bioRxiv · Apr 12, 2021Biochemistry