J. L. Koetsier

Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAFV600E-induced cellular senescence in human melanocytes

The paper shows that loss of desmoglein 1 in keratinocytes reduces senescence in BRAFV600E-expressing melanocytes by promoting NTN4 expression.

Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche

The paper shows melanoma cells exploit keratinocyte Dsg1 reduction via paracrine signaling to enhance tumor spread through CXCL1/CXCR2 and Snai2/Grhl1 pathways.

PP2A-B55α controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus

The paper identifies PP2A-B55α as a phosphatase regulating desmoplakin phosphorylation and intercellular adhesion in keratinocytes.

Epidermal Stratification Requires Retromer-Mediated Desmoglein-1 Recycling

This study identifies retromer-mediated recycling of Desmoglein-1 as essential for epidermal stratification and differentiation.

Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

This study investigates the systemic inflammatory response in Dsg1-deficient mice and humans, revealing a psoriatic-like IL-17-skewed inflammation due to genetic Dsg1 loss.

Desmosomes polarize mechanical signaling to govern epidermal tissue form and function

This study shows desmosomes and intermediate filaments regulate mechanical polarization in epidermis, influencing layer-specific functions and barrier formation.

Keratinocyte desmoglein 1 regulates the epidermal microenvironment and tanning response

This study shows that Dsg1 in keratinocytes regulates melanocyte communication and tanning by affecting cytokine secretion and melanin production.