Cancer BiologybioRxivPreprint
Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche
H. E. Burks, J. L. Pokorny, J. L. Koetsier…·K. J. Green
The paper shows melanoma cells exploit keratinocyte Dsg1 reduction via paracrine signaling to enhance tumor spread through CXCL1/CXCR2 and Snai2/Grhl1 pathways.
DOI 10.1101/2022.12.01.518424