Author

J. Kweon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Brenner· 2 shared C. Sun· 2 shared G. Jang· 2 shared H. F. Zhang· 2 shared R. Fang· 2 shared Y. Kim· 2 shared Y. Zhang· 2 shared A. L. Huffine· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

B. Brenner

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Multiscale imaging of corneal endothelium damage and effects of Rho Kinase inhibitor application in mouse models of acute ocular hypertension

Z. Cai, Y. Zhang, R. Fang, B. Brenner, J. Kweon, C. Sun, J. Goldberg, H. F. Zhang

The paper uses multiscale imaging to study corneal endothelium damage in mouse models, finding that Rho Kinase inhibitors reduce fully-distorted tight junctions under acute ocular hypertension.

bioRxiv · May 18, 2023Biophysics

Quantify nanoscopic alterations associated with mitochondrial dysfunctions using three-dimensional single-molecule localization microscopy

B. Brenner, Y. Zhang, J. Kweon, R. Fang, N. Sheibani, S. X. Zhang, C. Sun, H. F. Zhang

This paper introduces a quantitative method to analyze mitochondrial morphology using 3D single-molecule localization microscopy, validated with simulated data and tested on altered mitochondria.

bioRxiv · May 10, 2023 · PreprintBiophysics

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants

G. Jang, J. Kweon, Y. Kim

This study develops universal pegRNAs for CRISPR prime editing to correct multiple KRAS mutations in cancer cells, achieving up to 54.7% correction efficiency in HEK293T/17 cells.

bioRxiv · Dec 21, 2022 · PreprintBioengineering

Preprocessing of general stenotic vascular flow data for topological data analysis

C. Bresten, J. Kweon, X. Chen, Y.-H. Kim, J.-H. Jung

This paper introduces a preprocessing method to adapt topological data analysis for general stenotic vascular geometries, enabling accurate analysis of vascular disease using persistent homology.

bioRxiv · Jan 7, 2021 · PreprintBiophysics

Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

L. M. Godsel, Q. R. Roth-Carter, J. L. Koetsier, L. C. Tsoi, J. A. Broussard, G. N. Fitz, S. M. Lloyd, J. Kweon, A. L. Huffine, H. E. Burks, M. Hegazy, S. Amagai, P. W. Harms, J. L. Johnson, G. Urciuoli, , K. J. Green

This study investigates the systemic inflammatory response in Dsg1-deficient mice and humans, revealing a psoriatic-like IL-17-skewed inflammation due to genetic Dsg1 loss.

bioRxiv · Dec 1, 2020 · PreprintImmunology

Engineered Prime Editors with PAM flexibility

J. Kweon, J.-K. Yoon, A.-H. Jang, H. R. Shin, J.-E. See, G. Jang, J.-I. KIM, Y. Kim

This paper describes engineered prime editors that expand target site range by using PAM-flexible Cas9 variants.

bioRxiv · Nov 10, 2020Bioengineering