Author

J. Lasham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein design· 1

Frequent Co-Authors

V. Sharma· 4 shared V. Zickermann· 3 shared A. Djurabekova· 2 shared J. Vonck· 2 shared O. Haapanen· 2 shared A. Kipar· 1 shared D. J. Mills· 1 shared E. Galemou Yoga· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiophysics

V. Sharma

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Role of protonation states in stability of molecular dynamics simulations of high-resolution membrane protein structures

J. Lasham, A. Djurabekova, V. Zickermann, J. Vonck, V. Sharma

This study shows that using pre-determined protonation states in MD simulations improves structural accuracy for membrane proteins, highlighting the importance of protonation state calculations before simulations.

bioRxiv · Aug 24, 2023Biophysics

Nanobody engineering for SARS-CoV-2 neutralization and detection

L. Hannula, S. Kuivanen, J. Lasham, R. Kant, L. Kareinen, M. Bogacheva, T. Strandin, T. Sironen, V. Sharma, P. Saviranta, A. Kipar, O. Vapalahti, J. T. Huiskonen, I. Rissanen

This study engineers nanobodies to neutralize SARS-CoV-2 variants and develop a detection assay, showing high potency against some variants but limitations against others.

bioRxiv · Sep 14, 2022Microbiology

Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I

J. Lasham, O. Haapanen, V. Zickermann, V. Sharma

The paper uses molecular dynamics simulations to study how quinone derivatives move through the Q tunnel in complex I and how this movement couples with protein conformational changes.

bioRxiv · Jun 21, 2022Biophysics

High-resolution structure and dynamics of mitochondrial complex I - insights into the proton pumping mechanism

K. Parey, J. Lasham, D. J. Mills, A. Djurabekova, O. Haapanen, E. Galemou Yoga, H. Xie, W. Kühlbrandt, V. Sharma, J. Vonck, V. Zickermann

The paper presents a high-resolution cryo-EM structure of mitochondrial complex I from Yarrowia lipolytica, revealing proton translocation pathways and conformational changes linked to proton pumping.

bioRxiv · Apr 16, 2021Biochemistry