Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2
K. L. Hilligan, S. Namasivayam, C. S. Clancy, P. J. Baker, S. I. Old, V. Peluf, E. P. Amaral, S. D. Oland, D. O'Mard, J. Laux, M. Cohen, N. L. Garza, B. Lafont, R. F. Johnson, C. G. Feng, , A. Sher
This study shows that pre-existing IFN-gamma responses from bacterial infection reduce SARS-CoV-2 viral loads in the lungs and protect against disease in mice.
bioRxiv · Jul 15, 2023 · PreprintImmunology