In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia
V. J. Ford, W. N. Applefeld, J. Wang, J. Sun, S. B. Solomon, H. G. Klein, J. Feng, J. Lertora, P. TORABI-PARIZI, R. L. Danner, M. A. Solomon, M. Y. Chen, C. Natanson
This study shows that cardiac dysfunction in septic shock occurs without high catecholamine levels or microvascular ischemia, and epinephrine infusions cause prolonged microvascular perfusion issues.
bioRxiv · Feb 5, 2024Physiology