Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation
K. Huang, M. Ashraf, L. Rohani, Y. Luo, A. Sacayanan, H. Huang, A. Haegert, S. Volik, F. Sar, S. LeBihan, J. Liew, J. D. Roberts, G. F. Tibbits, J. M. Churko, S. Sanatani, , Z. W. Laksman
This study uses patient-derived iPSC-CMs to show that a titin truncating variant increases arrhythmia susceptibility and disrupts sarcomere structure in both atrial and ventricular tissues.
bioRxiv · Mar 2, 2023 · PreprintCell Biology