Cell BiologybioRxivPreprint
Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation
K. Huang, M. Ashraf, L. Rohani…·Z. W. Laksman
This study uses patient-derived iPSC-CMs to show that a titin truncating variant increases arrhythmia susceptibility and disrupts sarcomere structure in both atrial and ventricular tissues.
DOI 10.1101/2023.03.02.530843