Author

S. LeBihan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

C. Collins· 2 shared H. Adomat· 2 shared A. Haegert· 1 shared A. Sacayanan· 1 shared B. Zhai· 1 shared C. C. Collins· 1 shared C. S. Hughes· 1 shared D. Brown· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

C. Collins

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

K. Huang, M. Ashraf, L. Rohani, Y. Luo, A. Sacayanan, H. Huang, A. Haegert, S. Volik, F. Sar, S. LeBihan, J. Liew, J. D. Roberts, G. F. Tibbits, J. M. Churko, S. Sanatani, , Z. W. Laksman

This study uses patient-derived iPSC-CMs to show that a titin truncating variant increases arrhythmia susceptibility and disrupts sarcomere structure in both atrial and ventricular tissues.

bioRxiv · Mar 2, 2023 · PreprintCell Biology

A bi-functional PARP-HDAC inhibitor with activity in Ewing sarcoma

L. Ramos, S. Truong, B. Zhai, J. Joshi, F. Ghaidi, M. M. Lizardo, T. Shyp, H. Adomat, S. LeBihan, C. C. Collins, J. Bacha, D. Brown, J. Langlands, W. Shen, N. Lallous, , M. Daugaard

This paper develops a dual PARP and HDAC inhibitor, kt-3283, showing enhanced cytotoxicity and efficacy in Ewing sarcoma models compared to single-agent inhibitors.

bioRxiv · Nov 10, 2022 · PreprintCancer Biology

High-flow Nano-chromatography Columns Facilitate Rapid and High-quality Proteome Analysis on Standard Nano-LC Hardware

C. S. Hughes, H. Adomat, S. LeBihan, C. Collins, P. Sorensen, G. B. Morin

This study demonstrates that high-flow nano-chromatography columns improve proteome analysis throughput without sacrificing data quality on standard nano-LC hardware.

bioRxiv · Dec 19, 2018 · PreprintBiochemistry