Cancer BiologybioRxivPreprint
Methionine synthase supports tumor tetrahydrofolate pools
J. Z. Wang, J. M. Ghergurovich, L. Yang, J. D. Rabinowitz
This study shows methionine synthase (MTR) is crucial for cells to avoid folate trapping and assimilate 5-methyl-THF into other folate species, supporting one-carbon metabolism and tumor growth.
DOI 10.1101/2020.09.05.284521