p66Shc is an apoptotic rheostat whose targeted ROS inhibition improves MI outcomes
L. Haslem, J. M. Hays, H. Schmitz…·F. A. Hays
This study identifies p66Shc as a stress-dependent apoptotic rheostat and shows that reducing its pro-apoptotic ROS production improves myocardial infarction outcomes in zebrafish.