Cancer BiologybioRxiv
Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer
E. S. Dahl, R. Buj, K. E. Leon…·K. M. Aird
This study identifies IDH1 as a therapeutic target in HGSC by showing its role in promoting metabolic adaptation and epigenetic repression, leading to senescence when inhibited.
DOI 10.1158/1541-7786.mcr-18-1233