Author

J. M. Posimo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. C. Brady· 2 shared T. Tsang· 2 shared A. A. Gudiel· 1 shared C. J. Chang· 1 shared C. Y.-S. Chung· 1 shared D. M. Feldser· 1 shared J. M. Davis· 1 shared M. Cicchini· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

D. C. Brady

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Author profile →

2 papers

Recent·Most cited

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

T. Tsang, J. M. Posimo, A. A. Gudiel, M. Cicchini, D. M. Feldser, D. C. Brady

This study identifies copper as a regulator of ULK1/2 kinase activity in lung adenocarcinoma, showing that copper chelation can inhibit autophagy and tumor growth.

bioRxiv · Oct 24, 2019Cancer Biology

Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism

C. Y.-S. Chung, J. M. Posimo, S. Lee, T. Tsang, J. M. Davis, D. C. Brady, C. J. Chang

This paper introduces a ratiometric FRET copper probe, FCP-1, to image labile Cu(I) pools in live cells and shows oncogene-driven changes in glutathione metabolism reduce labile copper availability.

bioRxiv · Jun 24, 2019Biochemistry