Author

T. Tsang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

D. C. Brady· 3 shared J. M. Posimo· 2 shared A. A. Gudiel· 1 shared B. E. Schaffer· 1 shared C. J. Chang· 1 shared C. Mesaros· 1 shared C. Y.-S. Chung· 1 shared D. D. Winkler· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

D. C. Brady

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

S. L. Campbell, C. Mesaros, L. Izzo, H. Affronti, T. Tsang, M. Noji, B. E. Schaffer, K. Sun, S. Trefely, S. Kruijning, J. Blenis, I. A. Blair, K. E. Wellen

This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.

bioRxiv · Sep 13, 2020Cancer Biology

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

M. Grasso, G. J. Bond, Y.-J. Kim, K. B. Alwan, S. Boyd, M. M. Dzebo, S. Valenzuela, T. Tsang, N. A. Schibrowsky, M. L. Matthews, G. M. Burslem, P. Wittung-Stafshede, D. D. Winkler, N. J. Blackburn, R. Marmorstein, D. C. Brady

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.

bioRxiv · May 1, 2020 · PreprintBiochemistry

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

T. Tsang, J. M. Posimo, A. A. Gudiel, M. Cicchini, D. M. Feldser, D. C. Brady

This study identifies copper as a regulator of ULK1/2 kinase activity in lung adenocarcinoma, showing that copper chelation can inhibit autophagy and tumor growth.

bioRxiv · Oct 24, 2019Cancer Biology

Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism

C. Y.-S. Chung, J. M. Posimo, S. Lee, T. Tsang, J. M. Davis, D. C. Brady, C. J. Chang

This paper introduces a ratiometric FRET copper probe, FCP-1, to image labile Cu(I) pools in live cells and shows oncogene-driven changes in glutathione metabolism reduce labile copper availability.

bioRxiv · Jun 24, 2019Biochemistry