J. M. R. da Silva

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

The paper investigates the kinetics of carbon-carbon bond formation in fatty acid synthase, revealing how the enzyme's activity and fidelity are influenced by substrate length and dimeric cooperativity.

The paper identifies an 'alert-state' ribosome subpopulation (ASRs) that regulates cytokine-mediated processes by preferentially translating key mRNAs involved in immune responses.

Ribo-ODDR improves rRNA depletion in Ribo-seq by designing experiment-specific oligos, increasing sequencing depth and information yield.