Author

J. Mathur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Pathak· 4 shared J. Almeida· 2 shared Y. L. Lee· 2 shared B. Sarker· 1 shared C. Walter· 1 shared D. Cornish· 1 shared G. D. Longmore· 1 shared H. Zmuda· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiophysics

A. Pathak

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Cdh3-Lam332 signaling axis in a leader cell subpopulation controls protrusion dynamics and tumor organoid collective migration

P. Y. Hwang, J. Mathur, Y. Cao, J. Almeida, D. Cornish, M. Clarke, A. Pathak, G. D. Longmore

The paper identifies a Cdh3-Lam332 signaling axis in a subset of leader cells that drives protrusion dynamics and collective migration in tumor organoids.

bioRxiv · May 10, 2022 · PreprintCancer Biology

Mechanically primed cells transfer memory to fibrous matrices for persistent invasion

J. Almeida, J. Mathur, Y. L. Lee, B. Sarker, A. Pathak

The paper shows that cells primed by stiff matrices apply higher forces and align collagen fibers for sustained invasion, demonstrating mechanical memory transfer between cells and matrices.

bioRxiv · May 2, 2022 · PreprintBiophysics

Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing physical function of leader cells

Y. L. Lee, J. Mathur, C. Walter, H. Zmuda, A. Pathak

This study shows that dense matrix obstructions disrupt collective epithelial migration by altering cell stiffness, leader-follower dynamics, and communication, with implications for disease mechanotypes.

bioRxiv · Apr 28, 2022Biophysics

Mechanical memory in cells emerges from mechanotransduction with transcriptional feedback and epigenetic plasticity

J. Mathur, V. Shenoy, A. Pathak

This paper proposes a theoretical framework explaining long-term mechanical memory in cells by integrating transcriptional feedback and epigenetic plasticity with mechanotransduction.

bioRxiv · Mar 20, 2020 · PreprintBiophysics