M. Clarke

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

Identification of Fusarium Head Blight resistance in Triticum timopheevii accessions and characterisation of wheat-T. timopheevii introgression lines for enhanced resistance.

The paper identifies FHB-resistant Triticum timopheevii accessions and shows that introgression of chromosome 3G from these accessions into wheat enhances FHB resistance.

A Cdh3-Lam332 signaling axis in a leader cell subpopulation controls protrusion dynamics and tumor organoid collective migration

The paper identifies a Cdh3-Lam332 signaling axis in a subset of leader cells that drives protrusion dynamics and collective migration in tumor organoids.

Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

This paper presents a cryo-EM structure of the FANCI-FANCD2 complex bound to DNA, showing how ubiquitination dynamics regulate its function in DNA repair.

Temporin B forms hetero-oligomers with Temporin L, modifies its membrane activity and increases the cooperativity of its antibacterial pharmacodynamic profile

This study shows that temporin B enhances the antibacterial cooperativity of temporin L by forming hetero-oligomers, altering membrane interaction and increasing efficacy against EMRSA-15.

In vitro coinfection by influenza A virus and respiratory syncytial virus generates hybrid viral particles with altered structure and tropism

This study shows that co-infection of human lung cells with influenza A and respiratory syncytial viruses produces hybrid viral particles with altered structure and immune evasion capabilities.

LMO2 is critical for early metastatic events in breast cancer

The paper identifies LMO2-expressing tumor cells as metastasis-initiating cells and shows LMO2-STAT3 signaling promotes breast cancer metastasis.

In-planta Gene Targeting in Barley using Cas9, with and without Geminiviral Replicons

This study demonstrates successful heritable gene targeting in barley using Cas9 without a replicon, but fails to achieve heritable events with a replicon despite high repair template copy numbers.

Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPG

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes

This study presents the cryo-EM structure of PspA and shows its ability to remodel bacterial membranes through ESCRT-III-like mechanisms.

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

The paper determines the structure of VP40 matrix layers in Ebola and Marburg virus-like particles, revealing they are locally ordered assemblies of VP40 dimers forming 2D lattices.

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

This study identifies how ubiquitination of FANCI and FANCD2 stabilizes the ID2 complex on DNA, enhancing its affinity for double-stranded DNA and protecting ubiquitin from deubiquitination.

Identification of histological features to predict MUC2 expression in colon cancer tissues

The paper identifies histological features, such as large nuclear area, associated with MUC2 expression in colon cancer tissues using TCGA data.

Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation

This study shows Usp16 modulates Wnt signaling in tissues by regulating Cdkn2a, affecting stem cell expansion and regeneration, and identifies therapeutic implications for diseases like Down Syndrome.