A. Pathak

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

3D Imaging Reveals Changes in the Neurovascular Architecture of the Murine Calvarium with Aging

This study uses 3D imaging to analyze changes in the neurovascular architecture of the murine calvarium across aging, revealing age-related nerve loss and vascular changes.

Oviposition status and sugar availability influence measures of transmission potential in malaria-infected mosquitoes.

This study shows that oviposition status and sugar availability affect malaria parasite transmission potential in mosquitoes.

Microbiome Analysis of the Eastern Oyster As a Function of Ploidy and Seasons

The paper analyzes the microbiome of eastern oysters (Crassostrea virginica) across ploidy and seasons, finding Psychrobacter as a dominant genus with functional roles in nitrogen cycling.

Antibiotic-degrading resistance changes bacterial community structure via species-specific responses

The paper investigates how antibiotic-degrading resistance in one species affects multispecies bacterial communities, finding that species benefiting most are those that grow best at degraded antibiotic concentrations.

Transitions in density, pressure, and effective temperature drive collective cell migration into confining environments

This study shows that collective cell migration through confining environments involves transitions in density, pressure, and effective temperature, with cancer-like cells showing reduced sensitivity to these changes.

Epithelial multicellular clustering enabled by polarized macrophages on soft matrices

This study shows that M1 macrophages on soft matrices promote epithelial multicellular clustering, while stiff matrices inhibit it, highlighting the role of mechanical and immune factors.

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

This study evaluates a new live-attenuated LSD vaccine, showing it is safe, immunogenic, and effective in protecting cattle against LSD with high seroconversion rates.

Fast yet force-effective mode of supracellular collective cell migration on aligned fibers due to extracellular force transmission

The paper shows that aligned extracellular fibers enable faster, more efficient collective cell migration by enhancing force transmission and front stabilization.

Synaptotagmin-9 and Tomosyn-1 molecular complex regulates Stx1A SNAREs to inhibit insulin secretion from pancreatic beta-cells

This study shows that synaptotagmin-9 inhibits insulin secretion by forming a complex with Tomosyn-1 and Stx1A, reducing SNARE complex formation in pancreatic beta-cells.

Dehydration alters transcript levels in the mosquito midgut, likely facilitating rapid rehydration

This study shows dehydration alters midgut gene expression in Aedes aegypti, enabling faster rehydration after bloodfeeding and potentially affecting pathogen transmission.

Acinetobacter baumannii represses type VI secretion system through an Mn2+-dependent sRNA-mediated regulation

This study identifies an Mn2+-dependent small RNA-mediated regulation of T6SS in A. baumannii, revealing how Mn2+ influences sRNA binding to repress T6SS.

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

Nuclear export inhibition jumbles epithelial-mesenchymal states and gives rise to migratory disorder in healthy epithelia

This study shows that inhibiting nuclear export disrupts epithelial-mesenchymal states and affects collective cell migration in healthy epithelia.

SAM-dependent viral MTase inhibitors: herbacetin and caffeic acid phenethyl ester, structural insights into dengue MTase

The paper identifies herbacetin and caffeic acid phenethyl ester as inhibitors of dengue and chikungunya virus MTases, revealing their mechanism of action and antiviral efficacy.

A Cdh3-Lam332 signaling axis in a leader cell subpopulation controls protrusion dynamics and tumor organoid collective migration

The paper identifies a Cdh3-Lam332 signaling axis in a subset of leader cells that drives protrusion dynamics and collective migration in tumor organoids.

Mechanically primed cells transfer memory to fibrous matrices for persistent invasion

The paper shows that cells primed by stiff matrices apply higher forces and align collagen fibers for sustained invasion, demonstrating mechanical memory transfer between cells and matrices.

Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing physical function of leader cells

This study shows that dense matrix obstructions disrupt collective epithelial migration by altering cell stiffness, leader-follower dynamics, and communication, with implications for disease mechanotypes.

Sex, Age, and Parental Harmonic Convergence Behavior Affect the Immune Performance of Aedes aegypti Offspring

Mechanical memory in cells emerges from mechanotransduction with transcriptional feedback and epigenetic plasticity

This paper proposes a theoretical framework explaining long-term mechanical memory in cells by integrating transcriptional feedback and epigenetic plasticity with mechanotransduction.

Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration

This study identifies ephrin-B1 as a regulator of adult cardiomyocyte proliferation and heart regeneration, showing its role in blocking proliferation and its potential as a therapeutic target.

Meningitis pathogens evade immune responses by thermosensing

This study identifies RNA thermosensors in Streptococcus pneumoniae and Haemophilus influenzae that regulate virulence factors and help pathogens evade immune responses by sensing temperature.

Cryogenically preserved RBCs support gametocytogenesis of Plasmodium falciparum in vitro and gametogenesis in mosquitoes.

This study shows cryogenically preserved RBCs support gametocytogenesis of P. falciparum in vitro and gametogenesis in mosquitoes, with results comparable to or better than fresh RBCs.