Author

J. McCaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. A. Simpson· 2 shared P. Cao· 2 shared B. E. Barber· 1 shared F. J.I. Fowkes· 1 shared I. K. Jang· 1 shared J. Osborne· 1 shared J. R. Poespoprodjo· 1 shared J. S. McCarthy· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

J. A. Simpson

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3 papers

Recent·Most cited

Choice of spatial discretisation influences the progression of viral infection within multicellular tissues

T. Williams, J. McCaw, J. Osborne

This study shows that spatial discretisation choices in viral dynamics models affect model outputs, especially when diffusion rates are low.

Journal of Theoretical Biology · Sep 1, 2023Peer-reviewedImmunology

Characterisation of Plasmodium vivax lactate dehydrogenase dynamics in P. vivax infections

P. Cao, S. Kho, M. J. Grigg, B. E. Barber, K. A. Piera, T. William, J. R. Poespoprodjo, I. K. Jang, J. A. Simpson, J. McCaw, N. M. Anstey, J. S. McCarthy, S. Britton

This study models PvLDH dynamics in P. vivax infections using Bayesian inference, finding significant differences between ex vivo and in vivo PvLDH levels and half-lives.

bioRxiv · Jun 12, 2023 · PreprintBiophysics

Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling

J. A. Simpson, J. McCaw, P. Cao, F. J.I. Fowkes, S. Zaloumis, R. N. Price, S. Dini

This paper uses mathematical modeling to evaluate the efficacy of triple artemisinin-based combination therapy (TACT) against Plasmodium falciparum malaria, showing that adding mefloquine improves parasitological outcomes despite drug resistance.

bioRxiv · May 27, 2018Pharmacology & Toxicology