P. Cao

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Vagus Nerve Stimulation Ameliorates Epilepsy via a Gut Microbiota-Butyrate-Vagus Nerve-Brain Axis

This paper shows that vagus nerve stimulation reduces seizures by altering gut microbiota and butyrate levels through a vagus nerve-dependent pathway.

Natural selection and evolution of mitochondrial genome in terrestrial and aquatic turbellarians

This study examines the mitochondrial genome evolution in turbellarians, finding greater selection pressure in aquatic species and identifying NAD4 as a key gene under positive selection.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Cross-continental variation of herbivore resistance in a global plant invader

The paper examines genetic differentiation in herbivore resistance traits among native and introduced populations of Japanese knotweed across different regions.

Characterisation of Plasmodium vivax lactate dehydrogenase dynamics in P. vivax infections

This study models PvLDH dynamics in P. vivax infections using Bayesian inference, finding significant differences between ex vivo and in vivo PvLDH levels and half-lives.

Tumor-specific neutrophils originating from meninges promote glioblastoma

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza viruses

This study develops a mathematical model to analyze viral dynamics in HP and LP influenza infections, finding HP viruses have higher infection rates and lower interferon production, leading to more severe tissue damage.

Prediction of brain functions from structural connectome using graph neural network

This paper uses a graph neural network to predict task-evoked fMRI responses from structural connectome data, revealing the importance of ipsilateral cortical regions for higher cognitive functions.

Structural basis for the assembly and electron transport mechanisms of the dimeric photosynthetic RC-LH1 supercomplex

The paper reports cryo-EM structures of the dimeric RC-LH1 supercomplex from Rhodobacter sphaeroides, revealing the architecture, assembly mechanism, and electron transport pathways involving PufX and PufY.

Structural basis for sterol sensing by Scap and Insig

This study determines the structure of the Scap/Insig-2 complex in the absence of 25HC, revealing structural insights into cholesterol sensing and regulatory mechanisms.

Emergent myxobacterial behaviors arise from reversal suppression induced by kin contacts

This study identifies how kin recognition in Myxococcus xanthus leads to emergent collective behaviors through suppression of cell reversals and formation of rotating aggregates.

Modelling The Effect of MUC1 on Influenza Virus Infection Kinetics and Macrophage Dynamics

This study models how MUC1 affects influenza virus infection and macrophage dynamics, finding it reduces viral reproduction and macrophage recruitment but not viral load.

GEMC1-MCIDAS transcriptional program regulates multiciliogenesis in the choroid plexus and acts as a barrier to tumorigenesis

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

A comparison of Remdesivir versus Au22Glutathione18 in COVID-19 golden hamsters: a better therapeutic outcome of gold compound

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

Mitochondria fragment and reassemble to initiate the formation and development of the nucleus

The paper shows mitochondria fragment and reassemble to form nuclei and intranuclear inclusions during nuclear development.

Modelling within-host macrophage dynamics in influenza virus infection

This study develops a mathematical model to explore the relationship between macrophage activation and viral shedding in influenza infection, revealing that macrophage depletion drives the negative correlation between activation and viral shedding.

Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity

The paper studies the evolution of a gene cluster in Solanaceae plants and its role in producing medium chain acylsugars through trichome-specific enzymes.

Genomic approaches reveal an endemic sub-population of gray wolves in Southern China

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

The paper reports the cryo-EM structure of tetrameric Ptch1 bound to ShhNp, revealing an asymmetric mechanism of Hh ligand inhibition.

Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling

This paper uses mathematical modeling to evaluate the efficacy of triple artemisinin-based combination therapy (TACT) against Plasmodium falciparum malaria, showing that adding mefloquine improves parasitological outcomes despite drug resistance.