LUBAC assembles a signaling platform at mitochondria for signal amplification and shuttling of NF-ĸB to the nucleus
Z. Wu, L. A. Berlemann, V. Bader, D. A. Sehr, E. Eilers, A. Covallero, J. Meschede, L. Angersbach, C. Showkat, J. B. Michaelis, C. Muench, B. Rieger, D. Namgaladze, M. G. Herrera, F. C. Fiesel, , K. F. Winklhofer
This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.
bioRxiv · May 27, 2022 · PreprintCell Biology