mTOR signaling regulates aberrant epithelial cell proliferative and migratory behaviors characteristic of airway mucous metaplasia in asthma
K. Kudrna, E. B. Staab, E. Eilers, P. Thomes, S. Maurya, S. L. Brody, T. A. Wyatt, K. L. Bailey, J. D. Dickinson
This study shows mTOR signaling drives aberrant epithelial behaviors in asthma, including proliferation and migration, and its inhibition reduces mucous metaplasia features.
bioRxiv · Feb 12, 2024 · PreprintCell Biology