Z. Wu

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling

This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.

Adapting Indirect Calorimetry to measure metabolic status of healthy and septic neonatal mice

This study evaluates the use of indirect calorimetry to measure metabolic status in neonatal mice, finding it viable for capturing physiological changes in health and septic states.

Infectious bronchitis virus vaccination, but not the presence of XCR1, is correlated with large differences in chicken caecal microbiota

This study compares the caecal microbiota of XCR1 knockout chickens with and without IBV vaccination, finding that vaccination, not XCR1 absence, significantly alters microbiota composition.

Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function

This study identifies msiCAT-tailing of mitochondrial proteins as a mechanism promoting glioblastoma growth by enhancing mitochondrial function and reducing apoptosis.

Control of Inflammatory Response by Tissue Microenvironment

This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.

Nicotine Ameliorates α-synuclein Pre-formed Fibril-Induced Behavioral Deficits and Pathological Features in Mice

This study shows nicotine reduces α-synuclein pathology and behavioral deficits in mice induced by human α-synuclein pre-formed fibrils.

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

This paper introduces a reagentless electrochemical method using self-assembled monolayers to detect small molecules in biological fluids.

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

The paper identifies ACE2 as a receptor for HKU5 coronaviruses from Pipistrellus abramus bats and investigates receptor tropism across merbecovirus clades.

Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

This study shows that chemoreceptor clusters and flagellar motors colocalize at the same pole in Pseudomonas aeruginosa, controlled by FlhF, and that CheY overexpression increases c-di-GMP, causing cell aggregation.

Regulation of host metabolism and defense strategies to survive neonatal infection

This study compares metabolic and defense strategies in preterm piglets infected with S. epidermidis, finding that survivors exhibit early resistance and later tolerance, linked to mitochondrial metabolism and improved survival.

A General-Purpose Non-invasive Neurotechnology Research Platform

The paper introduces a non-invasive neurotechnology platform with multi-modal sensors and integration into BCI2000, demonstrating its use in sleep monitoring and evoked potentials.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

This study shows that USP7 inhibition accelerates osseointegration in senile osteoporotic mice by enhancing macrophage efferocytosis and inducing apoptosis in aged BMSCs.

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression

The paper uses spatial transcriptomics and single-cell RNA sequencing to identify cellular organization patterns and immune microenvironment changes in early lung adenocarcinoma progression.

MiceVAPORDot: A novel automated approach for high-throughput behavioral characterization during E-cigarette exposure in mice

MiceVAPORDot automates behavioral analysis during e-cigarette exposure in mice, revealing phenotypes not detectable by traditional methods.

Alstrom Syndrome protein Alms1 is required for maintaining meiotic centriole engagement in spermatocytes of Drosophila

This study shows that Alms1 is essential for maintaining centriole engagement in Drosophila spermatocytes, with implications for understanding Alstrom Syndrome pathogenesis.

Cep290 is cooperatively maintained at basal body by Cep131-Cep162 and Cby-Fam92 modules

This study identifies two modules, Cep131-Cep162 and Cby-Fam92, that cooperatively maintain Cep290 at the basal body and initiate ciliogenesis.

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

This study shows that reducing glucose supply during infection improves survival in preterm infants by decreasing inflammation and maintaining normoglycemia, with liver involvement in these protective effects.