Author

J. Moecking

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Geyer· 3 shared E. Latz· 2 shared F. I. Schmidt· 2 shared G. Hagelueken· 2 shared L. D. J. Schiffelers· 2 shared A. Kopp· 1 shared A. vom Hemdt· 1 shared B. M. Kuemmerer· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

M. Geyer

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3 papers

Recent·Most cited

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

A. Kopp, G. Hagelueken, I. Jamitzky, J. Moecking, L. D. J. Schiffelers, F. I. Schmidt, M. Geyer

This study identifies nanobodies that inhibit GSDMD pore formation without affecting caspase cleavage, providing structural insights and potential drug design frameworks.

bioRxiv · Apr 20, 2023Biochemistry

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

L.-M. Jenster, K.-E. Lange, S. Normann, A. vom Hemdt, J. D. Wuerth, L. D. J. Schiffelers, Y. M. Tesfamariam, F. N. Gohr, L. Klein, I. H. Kaltheuner, D. J. Lapp, J. Mayer, J. Moecking, H. L. Ploegh, E. Latz, , F. I. Schmidt

This study identifies p38 kinases as a central signaling hub for NLRP1 inflammasome activation in response to ribotoxic stress and virus infection.

bioRxiv · Jan 24, 2022Immunology

Cryo-EM structure of the NLRP3 decamer bound to the cytokine release inhibitory drug CRID3

I. V. Hochheiser, M. Pilsl, G. Hagelueken, J. Moecking, M. Marleaux, R. Brinkschulte, E. Latz, C. Engel, M. Geyer

The paper determines the cryo-EM structure of NLRP3 bound to CRID3, revealing how the inhibitor stabilizes the protein and provides insights for drug development.

bioRxiv · Jul 22, 2021Immunology