A. Kopp

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

New insights into the dynamics of de novo gene origin

This study identifies young, polymorphic de novo genes in Drosophila melanogaster by sequencing tissue-specific transcriptomes, revealing their transient nature and challenges in reconstructing their origin.

Single-fly assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life

The paper presents 183 new genome assemblies for 179 drosophilid species using single-fly long-read sequencing, improving phylogenomic coverage and enabling a well-resolved multi-locus phylogeny.

Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae

The paper traces the evolutionary history of the Sex Peptide gene family and its receptor in 264 Drosophila species, finding divergent trajectories and weak coevolutionary signals.

Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

This study uses nanobodies to reveal GSDMD pore formation mechanism and shows their therapeutic potential in preventing pyroptosis.

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

This study identifies nanobodies that inhibit GSDMD pore formation without affecting caspase cleavage, providing structural insights and potential drug design frameworks.

Evolution and development of male-specific leg brushes in Drosophilidae

The paper investigates the evolution and development of male-specific sex brushes in Drosophilidae, finding similar developmental mechanisms across lineages despite uncertain phylogenetic origins.

Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression

The paper examines the loss of a male-specific sex comb in a Drosophilidae species, linking it to a secondary loss of doublesex (dsx) expression, and discusses implications for the evolution of sexual dimorphism.

Sex-specific evolution of a Drosophila sensory system via interacting cis- and trans-regulatory changes

This study investigates how sex-specific evolution of a Drosophila sensory system arises from interacting cis- and trans-regulatory changes in Poxn and dsx.

Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation

The paper determines the directionality of PYD filament growth by showing ASC elongates exclusively on the B-end of NLRP3 filaments, enabling a transition from NLRP3 nucleation to ASC elongation.

DrosoPhyla: genomic resources for drosophilid phylogeny and systematics

The paper develops genomic markers and constructs phylogenetic trees for 704 Drosophilidae species to clarify evolutionary relationships and resolve taxonomic uncertainties.

Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients

The paper examines how mosquito community composition influences virus prevalence along disturbance gradients, finding that increased host abundance, not infection rates, drives virus emergence in disturbed habitats.

Highly contiguous assemblies of 101 drosophilid genomes

The paper presents high-quality genome assemblies for 101 drosophilid lines using Oxford Nanopore sequencing, achieving high contig N50 and BUSCO completeness.

Mapping and DNA sequence characterisation of the Rysto locus conferring extreme virus resistance to potato cultivar ‘White Lady’

This study identifies the Rysto gene locus in potato, narrows it to 1 Mb, and discovers six NBS-LRR-type resistance genes, including two closely related to known resistance genes.