Lysosomal acid lipase-activity as a novel target to efficiently address triple-negative breast cancer high malignancy
H. Steigerwald, T. Bozzetti, M. Tams, J. On, G. Hoffmann, J. Lambertz, K. Weidele, S. Treitschke, F. Reinhardt, A. Kulik, N. Krawczyk, D. Niederacher, H. Neubauer, C. Werno, T. Rau, , K. Esser
This study shows that inhibiting lysosomal acid lipase (LIPA) reduces breast cancer stemness and sensitizes triple-negative breast cancer (TNBC) cells to chemotherapy, suggesting LIPA as a novel therapeutic target.
bioRxiv · Oct 1, 2023 · PreprintCancer Biology