Author

K. Esser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Niederacher· 2 shared H. Neubauer· 2 shared T. Fehm· 2 shared A. Crowther· 1 shared A. Hulme-Beaman· 1 shared A. Jamieson· 1 shared A. Kulik· 1 shared A. Linderholm· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Niederacher

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of a Bipyrimidineamide based α-Helix Mimetic Lead Compound for efficient Targeting of MDM2 in Triple-Negative Breast Cancer

J. L. On, V. Woloschin, F. Gier, J.-W. Tu, S. Bhatia, T. Lenz, K. Stühler, D. Niederacher, H. Neubauer, T. Fehm, T. Kurz, K. Esser

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.

bioRxiv · Mar 2, 2024 · PreprintCancer Biology

Lysosomal acid lipase-activity as a novel target to efficiently address triple-negative breast cancer high malignancy

H. Steigerwald, T. Bozzetti, M. Tams, J. On, G. Hoffmann, J. Lambertz, K. Weidele, S. Treitschke, F. Reinhardt, A. Kulik, N. Krawczyk, D. Niederacher, H. Neubauer, C. Werno, T. Rau, , K. Esser

This study shows that inhibiting lysosomal acid lipase (LIPA) reduces breast cancer stemness and sensitizes triple-negative breast cancer (TNBC) cells to chemotherapy, suggesting LIPA as a novel therapeutic target.

bioRxiv · Oct 1, 2023 · PreprintCancer Biology

Palaeogenomic analysis of black rat (Rattus rattus) reveals multiple European introductions associated with human economic history

H. Yu, A. Jamieson, A. Hulme-Beaman, C. J. Conroy, B. Knight, C. Speller, H. Al-Jarah, H. Eager, A. Trinks, G. Adikari, H. Baron, B. Böhlendorf-Arslan, W. Bohingamuwa, A. Crowther, T. Cucchi, , Sanma

This study uses ancient DNA to trace the introduction and population history of black rats in Europe, linking genetic changes to historical events like the Roman Empire's decline and the Plague Pandemic.

bioRxiv · Apr 14, 2021Evolutionary Biology