Cancer BiologybioRxivPreprint
Lysosomal acid lipase-activity as a novel target to efficiently address triple-negative breast cancer high malignancy
H. Steigerwald, T. Bozzetti, M. Tams…·K. Esser
This study shows that inhibiting lysosomal acid lipase (LIPA) reduces breast cancer stemness and sensitizes triple-negative breast cancer (TNBC) cells to chemotherapy, suggesting LIPA as a novel therapeutic target.