Long-term survival and induction of operational tolerance to murine islet allografts through the co-transplantation of cyclosporine A eluting microparticles
P. Kuppan, J. Wong, S. Kelly, J. Lin, J. Worton, C. Castro, J. Paramor, K. Seeberger, C. C. Anderson, G. S. Korbutt, A. R. Pepper
This study shows that localized cyclosporine A delivery via microparticles combined with CTLA4-Ig reduces islet allograft rejection and induces operational tolerance in mice.
bioRxiv · Feb 14, 2023 · PreprintImmunology